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Ningetinib Tosylate

CAS No. 1394820-77-9

Ningetinib Tosylate ( —— )

Catalog No. M23552 CAS No. 1394820-77-9

Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ningetinib Tosylate
  • Note
    Research use only, not for human use.
  • Brief Description
    Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
  • Description
    Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    TAM Receptor
  • Recptor
    AXL;c-Met;VEGFR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1394820-77-9
  • Formula Weight
    728.8
  • Molecular Formula
    C38H37FN4O8S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:8 mg/mL (10.98 mM; Need ultrasonic and warming)
  • SMILES
    O=C(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OCC(C)(O)C)=CC=C45)C(F)=C3.CC6=CC=C(S(=O)(O)=O)C=C6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ning Xi, et al. Abstract 1755: CT053PTSA, a novel c-MET and VEGFR2 inhibitor, potently suppresses angiogenesis and tumor growth. Cancer Res 2014;74(19 Suppl):Abstract nr 1755.
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